18 (0.22)  1.03 (0.16)  0.0001 0.0559 0.0003 Hip BMD 1.09 (0.20)  0.97 (0.15)  0.0002 0.0096 0.0071 FN BMD 0.92 (0.20)  0.81 (0.14)  0.0001 0.0032 0.0103 CT 0.18 (0.04)  0.15 (0.03)  0.0001 0.0029 0.0042 CSA 3.13 (0.77)  2.83 (0.64)  0.0030 0.0150 0.0510 BR 10.71 (2.92)  12.04 (2.73)  0.0170 0.1140 click here 0.0710 Presented are mean (SD) [observation number]. In the total sample, age and gender were adjusted. In the gender-stratified analyses, age was adjusted
as a covariant. Marked in bold are data that remained significant after Bonferroni correction”
“Introduction Hand radiographs are obtained routinely in order to determine the bone age as part of the workup
of a variety of disorders related to growth and maturation in children. Bone age is a better assessment of the child’s stage of physiological development than the chronological age; for instance, the menarche and the growth spurt occur in relatively narrow intervals of bone age . In recent years, there has been an increasing interest in assessing bone mass in paediatric endocrinology, and the traditional bone density methods, dual-energy X-ray absorptiometry (DEXA) and peripheral quantitative computed tomography (pQCT), have been adapted to the paediatric population [2, 3]. A bone mass measurement is often judged relative to bone age rather than age. The determination of bone age LY2835219 price has recently been automated by the BoneXpert method which locates 15 bones in the hand, including all the metacarpals, and assigns a bone age value to each bone [4–7]. In view of this new technology, it is logical to investigate the best way to determine bone mass from the bone Sulfite dehydrogenase age radiographs by an automated version of the classical method of radiogrammetry which was popular in the 1960s [8–10]). Rijn et al.  presented a study of automated radiogrammetry in children. This work employed the Pronosco/Sectra X-posure System to determine digital
X-ray radiogrammetry (DXR)-bone mineral density (BMD), which was originally developed for adults but used by them to analyse a paediatric population. Their results were encouraging, but the method tended to reject images at ages below 10 years, and it was not able to adapt the size of the measurement region to the size of the hand. The aim of this paper is to present a dedicated method for assessing bone mass of children using conventional radiographs of the hand. We perform a systematic analysis to determine the index that best accommodates the highly variable size of the paediatric hand, we present a reference database for healthy Caucasian European children, and we determine the EX 527 cost precision of the method. Methods Data The subjects’ radiographs are derived from three studies: The Sjaelland study: 1,867 healthy Caucasian subjects (median age 11.