The demographics, symptoms, vital signs, and laboratory test values in the MSSA group (n = 118) and the MRSA group (n = 11) were compared with use of univariate analysis. Multivariate logistic regression with backward stepwise selection was then used to identify independent multivariate predictors of MRSA osteomyelitis, and each of these predictors was subjected to receiver operating characteristic curve analysis to determine the optimal cutoff value. Finally, a prediction algorithm selleckchem for differentiating between MRSA and MSSA osteomyelitis on the basis of these independent predictors was constructed.
Results: Patients with MRSA osteomyelitis differed significantly from those with
MSSA osteomyelitis with regard to non-weight-bearing status, antibiotic use at presentation, body temperature, hematocrit value, heart Screening Library high throughput rate, white blood-cell count, platelet count, C-reactive protein level, and erythrocyte sedimentation rate. Four significant independent multivariate predictors were identified: a temperature of >38 degrees C, a hematocrit value of <34%, a white blood-cell count of >12,000 cells/mu L, and a C-reactive protein level of >13 mg/L. The predicted probability of MRSA osteomyelitis, determined on the basis of the number of these predictors that a child satisfied, was 92% for all four predictors, 45% for three, 10% for two, 1% for one,
and 0% for zero predictors. Receiver
operating characteristic curve analysis was used to evaluate the predictive accuracy of the number of multivariate predictors, PRT062607 mouse and this analysis revealed a steep shoulder and an area under the curve of 0.94 (95% confidence interval, 0.88 to 1.00).
Conclusions: Our proposed set of four predictors provided excellent diagnostic performance in differentiating between MRSA and MSSA osteomyelitis in children, and thus would be able to guide patient management and facilitate timely antibiotic selection.”
“Objectives: To evaluate trends and patterns in the prevalence of multiple pharmacy use (MPU) and to describe the number and types of pharmacies used by multiple pharmacy users from 2003 to 2009.
Design: Retrospective, cross-sectional, descriptive study.
Setting: United States from 2003 to 2009.
Participants 89,941 responses to the Medical Expenditure Panel Survey over 7 years.
Intervention: Analysis of respondent pharmacy use behaviors.
Main outcome measures: Annual use of more than one pharmacy and number and types of pharmacies used.
Results: MPU among patients using medications increased significantly during the study period (from 36.4% [95% CI 35.2-37.6] in 2003 to 43.2% [41.9-44.4] in 2009) a relative increase of 18.7% (P = 0.01). Multiple pharmacy users used between 2 and 17 different pharmacies per year to obtain prescription medications.