These proteins are discussed further below. (C) 2011 Elsevier Ire

These proteins are discussed further below. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Effects of exposure to environmentally realistic mixtures of persistent see more organic pollutants (POP) harvested from aquatic ecosystems in Norway were studied in an in vivo zebrafish model. POP were extracted from burbot

(Lota lota) liver from two separate lakes, Lake Losna and Lake MjOsa, and exposed to zebrafish through the diet in a two-generation study. Effects on survival, growth, sex ratio, and timing of puberty were investigated. In addition, the biomarkers 7-ethoxyresorufin O-deethylase (EROD) and vitellogenin (Vtg) were measured. The ratios of contaminant levels in

extracts collected from Lake MjOsa:Lake Losna were 6, 10, and 270 for polychlorinated Linsitinib concentration biphenyls (PCB), dichlorodiphenyltrichloroethanes (DDT), and polybrominated diphenyl ethers (PBDE), respectively. The concentration range of POP measured in zebrafish was lower than in burbot originating from Lake MjOsa, but comparable to concentrations previously reported in humans and wildlife. The results showed that exposure to environmentally realistic mixtures of POP exerted a negative effect on survival of fish in both generations. The marked drop in survival during 9-20 days post fertilization (dpf) suggested that Megestrol Acetate this period may be a critical window for development. In both generations an earlier onset of puberty was observed and a higher proportion of males

than females was noted in exposed fish compared to controls. Suprising effects of exposure were found on body weight. In the first generation (F0), body weight was significantly higher in both exposure groups compared to controls, while in the next generation (F1) the same exposures were associated with a decrease in body weight. Zebrafish exposed to relatively low quantities of POP showed a significant induction of biomarkers (EROD and Vtg), while fish exposed to higher exposure doses did not demonstrate induction.”
“The transcription factor E2F1 is upregulated when cerebellar granular neurons (CGNs) undergo apoptosis under potassium deprivation. In this study, we examined the effects of E2F1 upregulation on the survival and death of CGNs isolated from C57 mice and Sprague-Dawley (SD) rats. Plasmid- and adenovirus-mediated expression of E2F1 dose-dependently induced apoptosis in mouse CGNs but unexpectedly failed to induce apoptosis in rat CGNs. Caspase 3, a marker for neuronal apoptosis, was significantly activated by ectopic E2F1 expression in mouse CGNs but not in rat CGNs.

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