“
“Device loss of Combretastatin A4 BaxSr1-xTiO3 (BST, x=0.5 and 0.6)

film-based interdigitated capacitors as a function of frequency (1-20 GHz) at room temperature is observed to range broadly from less than 0.01 to larger than 1 while the commonly observed device losses are around 0.05. Frequency dependence of the device loss tends to be larger for the higher device losses (>0.05) and at the higher frequencies (>10 GHz). The various characteristics of the microwave device loss are examined by analyzing the complex power applied in the devices, P=P-active+jP(reactive), where P-active is the dissipated power and P-reactive is the stored power in the devices. The dissipated power at the devices (P-active), subsequently resulting in the device loss, e.g., device loss=-P-active/P-reactive, is well fitted with the dissipated powers associated with the dielectric resistance and the electrode resistance (including the conduction and radiation resistances) of the devices.”
“Cytokines are small proteins secreted by leukocytes in blood in response to infections, Apoptosis inhibitor thus offering valuable diagnostic information. Given that the same cytokines may be produced by different leukocyte subsets in blood, it is beneficial to connect production of cytokines to specific cell types. In this paper, we describe integration

of antibody (Ab) microarrays into a microfluidic device to enable enhanced cytokine detection. The Ab arrays contain spots specific to cell-surface antigens as well as anti-cytokine detection spots. Infusion of blood into a microfluidic device results in the capture of specific leukocytes (CD4 T-cells) and is 3MA followed by detection of secreted cytokines on the neighboring Ab spots using sandwich immunoassay. The enhancement of cytokine signal comes from leveraging the concept of reconfigurable microfluidics. A three layer polydimethylsiloxane microfluidic device is fabricated so as to contain six microchambers (1 mm x 1 mm x 30 mu m) in the ceiling of the device. Once the T-cell capture is complete, the device is reconfigured by withdrawing

liquid from the channel, causing the chambers to collapse onto Ab arrays and enclose cell/anti-cytokine spots within a 30 nl volume. In a set of proof-of-concept experiments, we demonstrate that similar to 90% pure CD4 T-cells can be captured inside the device and that signals for three important T-cell secreted cytokines, tissue necrosis factor-alpha, interferon-gamma, and interleukin-2, may be enhanced by 2 to 3 folds through the use of reconfigurable microfluidics. (C) 2013 American Institute of Physics. [http://dx.doi.org.elibrary.einstein.yu.edu/10.1063/1.4795423]“
“The PedsQL (TM) (Pediatric Quality of Life Inventory (TM)) is a modular instrument designed to measure health-related quality of life (HRQOL) and disease-specific symptoms in children and adolescents ages 2-18.