Methods: We conducted a secondary analysis of
prospectively collected data from 29 United States cities that participate in the Cardiac Arrest Registry to Enhance Survival (CARES). Patients were included if they were >12 years of age and had a documented resuscitation attempt from October 1, 2005 through December 31, 2009. Hierarchical multivariable https://www.selleckchem.com/products/nutlin-3a.html logistic regression analyses were used to estimate the associations between age and sex groups and survival to hospital discharge.
Results: Females were less likely to have a cardiac arrest in public, was witnessed, or was treatable with defibrillation. Females in the 12-49 year old age group had a similar proportion of survival to hospital
discharge when compared to age-matched males (females 11.6% vs. males 11.2%), while males >= 50 years old were more likely to survive when compared to age matched females (females 6.9% vs. males 9.6%). Age stratified regression models demonstrated that 12-49 year old females had the largest association with survival to hospital discharge (OR 1.55, 95% CI 1.20-2.00), while females in the >= 50 year old age group had a smaller increased odds of survival to hospital discharge (OR 1.18, 95% CI 1.03-1.35), which only lasted until the age of 55 years (OR 1.12, 95% CI 0.97-1.29).
Conclusions: Younger aged females were associated with increased compound screening assay odds of survival despite being found with poorer prognostic arrest characteristics. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: To formulate carbomer gel to localize and target drug action in periodontal pockets.
Methods: Diclofenac sodium (DS, anti-inflammatory) and metronidazole hydrochloride (MH, antibacterial) were loaded in gelatin microspheres Veliparib using glutaraldehyde cross-linking. The microspheres were evaluated for drug loading, entrapment and encapsulation efficiency, particle size, drug release as well as by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC).
The microspheres were incorporated into carbomer gel and evaluated for drug release.
Results: Loading, entrapment and encapsulation efficiencies of DS in the microsphere were 23.4, 93.6, and 74.9 w/w%, respectively, while for MH the values were 21.5, 86.0 and 73.1 % w/w, respectively. Mean particle size of unloaded microspheres, DS- and MH-loaded microspheres was 33.5, 67.8 and 51.4 mu m, respectively. SEM showed spherical geometry of microspheres while DSC indicated the amorphous nature of t entrapped DS and MH. Sustained release of DS and MH over a 4-h period from the microspheres and gel was achieved.
Conclusion: Carbomer gel loaded with microspheres of diclofenac and metronidazole is a potential localized delivery system for the treatment inflammation and infection in periodontal pockets.