Group II (GUIDE) received a total of 410 doses at a cost of $184,500. Group III (POST) received 28 doses of r-EPO at a cost of $12,600.\n\nConclusion: Removal of erythropoietin from our trauma service anaemia practice management guideline did not result in increased blood utilization. However, it yielded a hospital acquisition cost savings of $171,900. (C) 2009 Elsevier Ltd. All rights reserved.”
“Objective: Physical and depressive disorders frequently co-occur, but effects of physical health on depression treatment outcomes have received little research. This study aimed to compare treatment outcomes between people with depressive GM6001 disorder

with and without comorbid physical disorders.\n\nMethods: A Korean nationwide sample of 723 people with depressive disorder initiated on antidepressant treatment, and re-evaluated at I, 2, 4, 8, and 12 weeks later. Assessment scales for evaluating depressive symptoms (HAMD), anxiety (HAMA), global severity (CGI-s), and functioning (SOFAS) were administered at baseline and every follow-up visit.

Achievement of remission or response was defined only when these check details were maintained to the 12 week study endpoint or to the last follow-up examination, if earlier, with the date of the first observed remission point applied as the timing of remission. Logistic regression and Cox proportional hazards models were used.\n\nResults: Of the sample, 247 (34%) had at least one physical P5091 disorder. This was associated with lower socioeconomic status and more severe depressive symptoms at baseline, but was not associated with any treatment related characteristics including antidepressant type and regimen, concomitant medications, side effects, and duration of treatment period. After adjustment, patients with physical comorbidity responded more slowly and less often – particularly in domains of anxiety, global severity, and functioning (all p-values <.005).\n\nConclusion: More intensive assessment and integrated treatment approaches are needed to facilitate treatment responses

for depressive disorders in people with physical comorbidity. Future comparative studies between conventional and integrated treatment approaches are indicated for depressive disorders with physical comorbidity. (C) 2011 Elsevier Inc. All rights reserved.”
“Background: Life events are assumed to be triggers for new mood episodes in bipolar disorder (BD). However whether life events may also be a result of previous mood episodes is rather unclear. Method: 173 bipolar outpatients (BD land II) were assessed every three months for two years. Life events were assessed by Paykel’s self-report questionnaire. Both monthly functional impairment due to manic or depressive symptomatology and mood symptoms were assessed.