2% of the articles. An improvement in reporting qualities with Rasch articles was noted over time.
In addition, only 11.4% of the articles provided a transformation table for interval scale measurement in clinical practice. Conclusion. The Rasch model has been increasingly used in rheumatology over the last 2 decades in a wide range of applications. The majority of the articles demonstrated reasonable quality of reporting. Improvements in quality of reporting over time were revealed.”
“Dragonfly cyclovirus (DfCyV), a new species of ssDNA virus discovered using viral metagenomics in dragonflies (family Libellulidae) from the Kingdom of Tonga. Metagenomic sequences of DfCyV were similar to viruses of the recently proposed genus Cyclovirus within the family Circoviridae. Specific PCRs resulted in the recovery of 21 DfCyV genomes from PP2 chemical structure Duvelisib three dragonfly species (Pantala flavescens, Tholymis tillarga and Diplacodes bipunctata). The 1 741 nt DfCyV genomes share >95% nucleotide identity and are classified into 11 subtypes representing a single strain. The DfCyV genomes share 48-63% genome-wide nucleotide identity with cycloviruses identified in human faecal samples. Recombination analysis
revealed three recombinant DfCyV genomes, suggesting that recombination plays an important role in cyclovirus evolution. To our knowledge, this is the first report of a circular ssDNA virus identified in insects, and the data
may help elucidate evolutionary links among novel Circoviridae recently identified in animals and environmental samples.”
“(-)-[F-18]Flubatine was selected for clinical imaging of (42) nicotinic acetylcholine receptors because of its high affinity and appropriate kinetic profile. A fully automated synthesis of (-)-[F-18]flubatine as a sterile isotonic solution suitable for clinical use is reported, as well as the first evaluation in nonhuman primates (rhesus macaques). (-)-[F-18]Flubatine was prepared by BKM120 chemical structure fluorination of the Boc-protected trimethylammonium iodide precursor with [F-18]fluoride in an automated synthesis module. Subsequent deprotection of the Boc group with 1-M HCl yielded (-)-[F-18]flubatine, which was purified by semi-preparative HPLC. (-)-[F-18]Flubatine was prepared in 25% radiochemical yield (formulated for clinical use at end of synthesis, n=3), >95% radiochemical purity, and specific activity=4647Ci/mmol (171.9GBq/mu mol). Doses met all quality control criteria confirming their suitability for clinical use. Evaluation of (-)-[F-18]flubatine in rhesus macaques was performed with a Concorde MicroPET P4 scanner (Concorde MicroSystems, Knoxville, TN). The brain was imaged for 90min, and data were reconstructed using the 3-D maximum a posteriori algorithm. Image analysis revealed higher uptake and slower washout in the thalamus than those in other areas of the brain and peak uptake at 45min. Injection of 2.