Aim of study is to assess the prevalence of PLMd and migraine and their relationship with disability and pain intensity in a pediatric sample, referred for migraine without aura by pediatricians.
After a preliminary sleep habits screening with the Sleep Disturbances Scale for Children, 34 migraine subjects affected by migraine without aura (20 M, 14 F) (mean age 9.08; SD +/- 2.28) and 51 volunteers healthy children (28 M, 23 F) (mean age 9.37; SD +/- 1.81) accepted to underwent overnight PSG recordings in the Sleep Laboratory of the Clinic of Child and Adolescent
Neuropsychiatry, in order to define the macrostructural sleep characteristics and the prevalence of PLMd. Subsequently, the migraineurs sample was studied in order to define the relationship between disability, pain intensity, therapeutical responsiveness and the presence buy SHP099 of PLMd.
In the migraineurs children group, the individuals with PLM pathological index (PLMI a parts per thousand yen 5) represent the 26.47% of sample and present higher frequency (p < 0.001), intensity (p < 0.001), duration (p = 0.006) and life impairment as scored in the PedMIDAS (p < 0.001) of headache Selleck GS-9973 and lower efficacy of prophylactic (p = 0.001) and acute (p = 0.006) pharmacological
treatment than MoA children without PLM pathological index.
This preliminary study indicates the potential value of the determination of the PLMd signs, and the importance of the PSG evaluation in children affected by migraine, particularly when the clinical and pharmacological management tend to fail in the attacks control.”
“Study PF-03084014 Design. Computed Tomographic Analysis of the Porcine Scoliosis Model.
Objective. To describe the spinal and rib cage modifications using computed tomography (CT).
Summary of Background
Data. Optimal development of nonfusion techniques for treatment of adolescent idiopathic scoliosis (AIS) requires a reliable large animal model that achieves spinal and rib cage modifications similar to AIS. Previous work has described the global 3-dimensional nature of the progressive deformity.
Methods. This IACUC-approved study includes 11 extracted scoliotic spines from a previous investigation. Scoliosis was induced through unilateral posterior ligament tethering of the spine via pedicle screw fixation, and ipsilateral rib cage tethering. CT analysis was used to quantify rib cage asymmetry, axial rotation, and wedging of the apical functional unit ( 2 vertebrae and intervening disc) for each specimen.
Results. The mean coronal Cobb angle was 55.7 (n = 11). Vertebral and intervertebral heights of the apical functional unit demonstrated convex heights (untethered) were always larger than concave ( tethered) heights ( P < 0.05). Axial rotation was maximal ( mean, 20) at 1 to 2 levels distal to the coronal apex.