Cortical thickness and perimeter were also measured. Biomechanical

properties were also derived from the cross-sectional parameters of the femoral neck, inter-trochanter, and shaft. Analysis of cross-sectional bone geometry and volumetric BMD The cross-sectional femoral neck data were based on the geometrical axis to calculate cortical CSA (in square centimeter), total CSA (in square centimeter), NCT-501 mouse volumetric cortical BMD (cortical vBMD; in milligram per cubic centimeter), total volumetric BMD (total vBMD; in milligram per cubic centimeter), total bone mass (in gram), and cortical bone mass (in gram). In this study, total CSA was defined as the estimated total mineralized area. Cortical thickness (in millimeter) and cortical perimeter (in centimeter) were also derived. FRAX597 supplier biomechanical parameters Because biomechanical parameters were determined on the principal axis, the cross-sectional moment of inertia (CSMI; in millimeters to the fourth power), the section modulus (SM; in cubic millimeter) and the buckling ratio (BR) were calculated from bone density and geometrical data. The CSMI is defined by the integration of the products of incremental CSA and the square of their distance from the center of mass (centroid).

The SM is the ratio of CSMI to the maximal distance of the material from the centroid, which is directly related to strength with respect to a corresponding bending stress. Due AZD1480 ic50 to local buckling, failure occurs on the compressive surface, and BR was calculated in this study as the maximal distance from the centroid divided by the average cortical thickness [9]. Reproducibility

of the analysis Florfenicol done by the QCT-Pro program was calculated by using five repeated measurements with visual matching each time from CT data sets without visible artifacts from seven healthy subjects. The coefficient of variation, as determined by the root mean square standard deviation divided by the mean, was 1.49 % for total vBMD, 2.63 % for cortical vBMD, 1.12 % for total mass, 1.71 % for total CSA, 2.11 % for cortical CSA, 2.11 % for cortical perimeter, and 3.58 % for cortical thickness at the femoral neck [10]. Statistics All statistical analyses were performed on subjects who had been randomized and had evaluable observations for QCT assessment both at baseline and post-dose (48 or 72 weeks). Paired and Student’s t tests, and chi-square test were used and Pearson’s correlation coefficients are shown. All p values calculated in the analysis were two-sided and were not adjusted for multiple testing. Statistical analyses were done with SAS version 9.1 (SAS Institute, Cary, USA). Results A total of 66 subjects were enrolled and randomly assigned to two treatment groups. There were 29 in the teriparatide group (age 66 to 83 years; mean ± SD, 74.2 ± 5.