The lack of very early diagnostics and remedy for customers with such diseases contributes to bad prognosis. A diet could be the primary treatment solution of numerous orphan conditions. A meal plan needs to be personalized and base on thorough examination of health condition. Individual diet therapy encourages an improvement of patient`s condition and enhances an impact of other types of treatment for settlement of metabolic conditions, loss of problem threat while increasing of life quality. This article summarizes the experience of remedy for kids with orphan conditions in the Department of Pediatric Gastroenterology, Hepatology and Nutrition Ultrasound bio-effects of Federal Research Centre for diet, Biotechnology and Food protection. 444 patients with hereditary problems of carbohydrate k-calorie burning, lipid k-calorie burning and much more uncommon diseases (tyrosinemia, lysosomal acid lipase deficit, fructosemia, urea cycle disturbances, α1-antitrypsine insufficiency etc.) have now been assessed into the division since 2008. The outcome regarding the examination and remedy for children with glycogen storage conditions (n=131), fructosemia (n=18), inherited disturbances of lipid metabolic rate (n=118) and other uncommon diseases tend to be represented into the paper. The monitoring of health condition can really help to improve therapy depending on character and seriousness of pathological process for benign span of the disease.The rise in the number of clients with allergic conditions, that are due to food allergy, is actually one of the leading dilemmas Peficitinib in vivo of the XXI century. Growing the spectral range of food allergens in charge of the introduction of food allergies raises the question of increasing understanding in this region for professionals. The content presents data on causally significant food allergens and food ingredients that cause the introduction of food allergies, also home elevators the main food proteins and their components active in the formation of cross-reactivity. Modern-day ways of molecular diagnostics and an algorithm for diagnosing meals allergies and meals intolerances tend to be presented.Dietary patterns genetic architecture perform an important role in pathogenesis and remedy for useful intestinal disorders. The aim – to execute literature review on contemporary ways to do health evaluation in practical gastrointestinal disorders and to summarize offered data on its role in evaluation of medical manifestations and treatment of these conditions. Material and methods. A search had been performed into the PubMed and Google scholar system if you use keywords “nutritional design”, “dietary structure”, in combination with “methodology”, “assessment”, “functional intestinal problems”, “GERD”, “gastroesophageal reflux disease”, “irritable bowel syndrome”, “IBS”, “small intestinal microbial overgrowth”, “treatment”. The inclusion criteria were variety of the report (original study); that they had to contain information on diet of patients with useful intestinal problems; primary digital data is present (sample size, design, diagnostic criteria, customers’ qualifications criteria, control team characteristics, in addition to results in quantitative qualities and measure of dispersion of values). Outcomes and conversation. Based on the data of 81 selected documents organized literary works analysis ended up being carried out. We summarized the information in the ways of meals patterns assessment, the information regarding the food patterns in customers with functional intestinal conditions (including gastroesophageal reflux illness and irritable bowel syndrome), clinical energy of the health evaluation with the use of food patterns. Evaluation of health habits in clients with useful intestinal conditions provides additional proof which allows to fix the diet of these clients more effectively, to produce greater results of treatment in smaller time, to lessen how many medicines, and may even be of use when it comes to improvement brand-new useful foods.The article provides contemporary information on the prevalence of overweight and obesity, provides updated information about customized programs for handling weight, specific suggestions for a heathier eating plan, adequate physical activity and lasting life style changes. It really is shown that nutritional therapy may be the standard treatment method in weight loss programs and is geared towards long-lasting upkeep of a bad energy stability in the patient’s system by restricting the calorie intake. A significant place in the content is devoted to making use of diet programs customized by calorie worth and macronutrient content which are recommended for overweight clients.