Firstly,
the clinical recognition and effective management of fungal infections in surgical settings is challenging and the strategy to reduce damages needs a multistep diagnostic approach to establish a certain diagnosis. Secondly, the study underlines the importance of culture and histological examination of surgical specimens, which could detect the presence of fungi even when blood cultures are negative. Finally, histological examination allows us to observe the quantity and the morphological aspects of budding Proteases inhibitor hyphae which can suggest a real overgrowth and a pathogenic role. More consideration needs to be given to selecting the appropriate antifungal agent for high-risk surgical patients. Consent Written informed consent was obtained from patients for publication of these Case Reports and any accompanying images. Geneticin purchase A copy of the written consent is available for review by the Editor-in-Chief of this journal. References 1. Chahoud J, Kanafani ZA, Kanj SS: Management of candidaemia and invasive candidiasis
in critically ill patients. Int J Antimicrob Agents 2013, 8:134–139. 2. Sartelli M, Catena F, Ansaloni L, Moore E, Malangoni M, Velmahos G, Coimbra R, Koike K, S63845 Leppaniemi A, Biffl W, Balogh Z, Bendinelli C, Gupta S, Kluger Y, Agresta F, Di Saverio S, Tugnoli G, Jovine E, Ordonez C, Augusto Gomes C, Pereira GA, Yuan KC, Bala M, Peev MP, Cui Y, Marwah S, Zachariah S, Sakakushev B, Kong
V, Ahmed A, et al.: Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study). World J Emerg Surg 2013, 8:1.PubMedCrossRef 3. Di Carlo P, Pantuso G, Cusimano A, D’Arpa F, Giammanco A, Gulotta G, Latteri AM, Madonia S, Salamone G, Mammina C: Two cases of monomicrobial intraabdominal abscesses due to KPC-3 Klebsiella pneumoniae ST258 clone. BMC Gastroenterol 2011, 11:103.PubMedCrossRef 4. Tortorano AM, Peman J, Bernhardt H, Klingspor L, Kibbler CC, Faure O, Biraghi E, Canton E, Zimmermann K, Seaton S, Grillot R, ECMM Working Group on Candidaemia: Epidemiology of candidaemia in Europe: results of 28-month European Confederation out of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis 2004, 23:317–322.PubMedCrossRef 5. Ables AZ, Blumer NA, Valainis GT, Godenick MT, Kajdasz DK, Palesch YY: Fluconazole prophylaxis of severe Candida infection in trauma and postsurgical patients: a prospective, double-blind, randomized, placebo-controlled trial. Infect Dis Clin Pract 2000, 9:169–175.CrossRef 6. Sartelli M, Viale P, Koike K, Pea F, Tumietto F, van Goor H, Guercioni G, Nespoli A, Tranà C, Catena F, Ansaloni L, Leppaniemi A, Biffl W, Moore FA, Poggetti R, Pinna AD, Moore EE: WSES consensus conference: Guidelines for first-line management of intra-abdominal infections. World J Emerg Surg 2011, 6:2.PubMedCrossRef 7.