Methods: Cross-sectional data of 646 mother-child pairs from the Jintan China Cohort Study were used in the analyses. Mother’s exposure to tobacco smoking at home, the workplace, and other places during pregnancy (for the determination of maternal ETS exposure) and children’s behaviors (via Child Behavior Checklist) were assessed when the children were 5-6 years old.
Logistic regression models were constructed to examine associations between maternal exposure to ETS during pregnancy and internalizing and externalizing behavior problems, adjusting for potential cofounders including child sex and parental characteristics.
Results: 37% of mothers reported ETS during pregnancy. Children of mothers exposed to ETS during pregnancy had higher scores for externalizing and total behavior problems, with 25% of children whose mothers were exposed to ETS compared
to 16% of children of unexposed mothers. After adjusting CYC202 supplier for potential confounders, ETS exposure was associated with a higher risk of externalizing behavior problems in offspring of exposed mothers (OR = 2.08, 95% confidence interval [CI] 1.27-3.43). Analysis after multiple imputations and sensitivity analysis further verified the association, but no dose-response relationship was found. ETS exposure, however, was not associated with internalizing or total behavior problems.
Conclusion: This study suggests that maternal ETS exposure during pregnancy may impact child behavioral development, particularly externalizing behaviors. (C) 2012 Elsevier Inc. All rights reserved.”
“The influence Erastin solubility dmso of two different dietary patterns on maternal fatty acid (FA) intake on the composition of umbilical cord blood plasma almost phospholipids and transitional breast milk was investigated. A 7-day dietary record was completed in the last trimester of pregnancy by women living in an inland and a coastal area of south-eastern China. The FA composition in maternal diet was calculated using the 2002 Chinese food
composition database. Cord blood and transitional breast milk samples were collected and their FA composition was analyzed by capillary gas-liquid chromatography. Mothers in the coastal area showed higher intake of long-chain polyunsaturated FA (LCPUFA) including docosahexaenoic acid (DHA, 22:6 omega) and eicosapentaenoic acid (EPA,20:5 omega 3) but lower linoleic acid (LA, 18:2 omega 6) and alpha-linolenic acid (ALA, 18:3 omega 3) than the mothers in the inland area. The intake of arachidonic acid (AA, 20:4 omega 6) did not differ between the two areas. LA ALA, AA and DHA in breast milk of day 5 reflected the maternal diet except that the EPA content in breast milk at day 5 was similar for the areas. LA, ALA and AA were lower and EPA higher in umbilical cord plasma phospholipids in infants from the costal compared to the inland area.