Recently, JAZF1/JJAZ1 gene fusion has been described as a defining feature of low-grade ESS (LGESS). However, its prevalence is variably reported, and the diagnostic utility has rarely been examined for cases showing various histological differentiation. Methods: To test the diagnostic utility of JAZF1/JJAZ1 gene fusion in difficult cases, we compared the prevalence of the JAZF1/JJAZ1 fusion gene in LGESS with and without histological differentiation.

Results: The JAZF1/JJAZ1 fusion transcript was detected in 18 of 21 LGESS (85.7%), including 14 classical LGESS (93%), four LGESS with diverse histological differentiation selleck (67%), and two with UES (28.6%). Positive AICAR in vivo cases included two LGESS with sex cord-like differentiation, one with osseous differentiation, and two UES. LGESS showing smooth muscle differentiation

revealed the fusion transcript only in the classic area. Direct sequencing analysis of two LGESS revealed a previously reported breakpoint at t(7;17)(p15;q21). Conclusions: The JAZF1/JJAZ1 fusion gene was identified in a significant proportion of LGESS showing secondary histological differentiation except in cases with smooth muscle differentiation. Thus, this fusion gene may be useful to confirm the diagnosis in difficult cases of LGESS.”
“Sodium-alginate/acrylamide (Na-alginate/AAm) cross-linked hydrogel was prepared by using gamma irradiation. The gel content and the water absorbency behavior of the obtained hydrogel were investigated. The thermal and morphological properties of the prepared

hydrogel were studied using thermogravimetric analysis and scanning electron NCT-501 supplier microscopy. The thermal stability of Na-alginate significantly changed when mixed with AAm. The adsorption of basic violet 7 dye on the prepared hydrogel was studied under different experimental conditions. The adsorption process for the basic dye was proven pH dependent. The maximum amount adsorbed (mg/g) of the Na-alginate/AAm for the dye was found to be 78.1.0 mg/g at pH 9.0. (c) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 1899-1906, 2011″
“Background: In multiple lung cancers (MLCs), distinction between intrapulmonary metastases and multiple primary tumors is important for staging and prognosis. In this study, we have investigated histopathologic prognostic factors of patients with MLCs. Methods: Histologic subtype, size differences, lobar location, lymphovascular invasion (LVI), size of the largest tumor, nodal status, number of tumors, morphology of tumor periphery, and immunohistochemical profiles using eight antibodies, were analyzed in 65 patients with MLCs. Results: There was no significant difference in the survivals of patients with multiple primary tumors and intrapulmonary metastases, as determined by the Martini-Melamed criteria (p = 0.654).