Symptomatic hand OA may cause functional impairment due to loss o

Symptomatic hand OA may cause functional impairment due to loss of strength, thus limiting the individual’s ability to perform daily tasks.

Conclusions: Several risk factors for hand OA have been identified; however, their

interrelationship is not clearly understood. The development of preventive strategies and future research goals is needed. (C) 2010 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 39:465-476″
“Objectives: Sleep disturbances frequently accompany chronic pain from osteoarthritis (OA), and their effective management may reflect successful treatment of chronic pain. The objective of this article is to provide a rationale for using improvement Ricolinostat in sleep as a marker for effective management of chronic OA pain with opioid analgesics. For this purpose, available evidence evaluating the relationship between successful management of chronic pain with opioids and improvements in sleep in patients with OA is reviewed.

Methods: We conducted find more a comprehensive

PubMed search to identify studies that systematically measured the impact of opioid treatment on pain and sleep parameters in the context of chronic pain from OA. Our search criteria included publication in a recognized peer-reviewed journal, randomized placebo-controlled design, and assessment of both pain intensity and sleep as outcomes.

Results: In each of the 10 placebo-controlled studies identified, concurrent improvements in pain intensity and measured sleep disturbances were observed in patients receiving the long-acting opioid analgesics under study. Improved overall sleep quality, reduced awakenings from pain, and increased duration of sleep were among the favorable changes observed in patients with OA treated with long-acting opioids.

Conclusions: Current evidence suggests that various long-acting opioid analgesics simultaneously achieve pain control and improve sleep. However, the complex interaction between

LY2157299 TGF-beta/Smad inhibitor reduced pain and improved sleep requires further study. (C) 2010 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 39:477-490″
“Objectives: To review current developments, regarding the pathophysiologic role of monocytes and macrophages in systemic lupus erythematosus (SLE).

Methods: We searched Medline for articles written in the English language using the following terms: monocyte(s) or macrophage(s) and lupus. Although our search spanned the years 1971 to 2008, the majority of the short-listed articles belonged to the period 2000 to 2008. Published literature on phenotypic and functional properties of monocytes/macrophages (Mo/M phi) in SLE was reviewed. References from identified articles were also selected. Currently available experimental data and their relevance to the pathogenesis of SLE are critically discussed.

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