Furthermore, the fact that the most complicated DRGs have a higher cost per day according to the regional government tax regulations regarding public service costs [16] and that these are marked with longer LOS makes the health costs for these groups shoot up. The same effect has been described in a multicenter study published by Hass [3]; the study pointed out that despite a higher cost of the material needed for LA,

the cost of the entire procedure is still 27,6% lower than OA due to similar operating times, lower LOS and a morbidity rate 5% lower for LA. Regarding the costs of the laparoscopy material, Chu [11] stated that the use of endoscopic learn more linear staplers is responsible for the elevated cost of LA (300$ per firing), whereas other methods for ligating the appendix and the mesoappendix are much cheaper, thus any of those more cost-effective methods ought to be used instead of endoscopic linear staplers. Thermocoagulation BMS202 concentration of the mesoappendix (by means of bipolar device of electrocautery) has been shown to be an effective and

much cheaper mean to control the appendicular artery [25–28] and, indeed, we have registered no hemorrhagic complications related to this method of controlling the appendicular artery. For the appendicular stump, we have used an intracavitary “handmade” suture as described because it is safe and the cost is far lower. Some authors maintain that the stapling takes only a few seconds (much less than a handmade suture) but they do Resminostat not bear in mind that preparing and correctly locating

the device also takes a time that is not taken into consideration on endorsing this claim [29]. Therefore, the main advantage of LA is in terms of LOS and complications. For this reason, Tiwari [12] published a retrospective analysis of 208.314 patients undergoing several laparoscopic procedures (including emergency LA) stratified in AG-881 in vitro different groups according to the severity of the disease and found a reduction in mortality rates, morbidity rates, ICU admissions, hospital readmissions in the following 30 postoperative days, lower LOS and significantly lower costs for all the laparoscopic procedures. Hence, the general conclusion of this large multicenter study is that laparoscopic approach for all these procedures is safe, efficient and cost-effective compared to open techniques. Gil Piedra [30] found that AL is far superior than OA in terms of complications arising in the most serious cases of AA (gangrenous and perforated). Focusing on morbidity (Table 2), we found a rate of 5% (2 cases) for LA, which is similar to the rate described by other authors. Nevertheless, morbidity rate for OA is significantly higher than in other centers [1, 5–10, 13, 14, 23, 24, 29], although Vallribera published a complication rate in the same fashion [31].